Decision Lab at UCSF (Chiong lab)

Fig. 1 Survey weighted proportions of U.S. dementia caregivers’ willingness to participate in a hypothetical dementia clinical trial with their care recipient

Leggins B, Hart DM, Jackson AJ, Levenson RW, Windon CC, Merrilees J, Chiong W.
Perceptions about dementia clinical trials among underrepresented populations: a nationally representative survey of U.S. dementia caregivers.

Alzheimers Research & Therapy. 2024;16(1):224.

PubMed Central PMC11476697
10.1186/s13195-024-01579-5
Preregistration
Open Data

Figure 1. Mr. U’s brain volumes compared to healthy controls.

Antoniou R, Callahan P, Kramer JH, Miller BL, Chiong W, Rankin KP.
Socioemotional dysfunction and the greater good: a case study.

Neurocase. 21:1-10.

10.1080/13554794.2024.2404682

Figure 1 of paper: Survey Weighted Proportions of US Adults' Preferences and Perceptions Regarding Closed-Loop Brain Implants.

Chen BB, Haeusermann T, Dada A, Hamilton RH, James JE, Fong KC, Dohan D, Chiong W.
Race-ethnicity, rurality, and age in prospective preferences and concerns regarding closed-loop implanted neural devices.

Journal of Neuropsychiatry and Clinical Neurosciences. 2024 Aug 22:appineuropsych20230190. Online ahead of print.

10.1176/appi.neuropsych.20230190
Preregistration
Open Data
Open Materials

photo-realistic image of a crystal ball on top of golden-yellow velour-like fabric against a deep blue background.

Hoy CW, Chiong W.
The ethical landscape of prodromal Parkinson disease: Considerations for shared decision-making and health equity.

Neurology. 2024; 102(11):e209522.

PubMed Central PMC10700017
10.1212/WNL.0000000000209522

A grid image showing six scans of grey matter in brains. The image is Figure 3 from the article that is linked.

Ngo S, Jackson AJ, Manivannan M, Young JC, Leggins B, Cryns NG, Tran ST, Grant HE, Knudtson MV, Chiong W.
Real world financial mismanagement in Alzheimer's disease, frontotemporal dementia, and primary progressive aphasia.

Journal of Alzheimer’s Disease. 2024; 99(1):251-262.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC11132181
10.3233/JAD-231021
Preregistration
Open Materials

Haeusermann T꙳, Liu EY꙳, Fong KC, Dohan D, Chiong W. ꙳(co-first authors)
Patient experiences of resection versus responsive neurostimulation for drug-resistant epilepsy.

Epilepsy & Behavior. 2024; 153:109707.

Open Access
PubMed Central PMC11185832
10.10.1016/j.yebeh.2024.109707

Photo-realistic image of a large pile of medicinal pills in various sizes, shapes, and colors.

Haeusermann T, Chiong W.
Ethical considerations in rapid and novel treatments in psychiatry.

Neuropsychopharmacology. 2024; 49(1):291-293.

Open Access
PubMed Central PMC10700644
10.1038/s41386-023-01635-y

photograph showing the back of a person's head who appears to be an adult with short brown hair. They are gazing at an electronic screen that reads 'Then how did he know your name'.

Sankaran N, Moses D, Chiong W, Chang EF.
Recommendations for promoting user agency in the design of speech neuroprostheses.

Frontiers in Human Neuroscience. 2023;17:1298129.

Open Access
PubMed Central PMC10619159
10.3389/fnhum.2023.1298129

A graph showing 'Change Relative to Baseline in Mean Monthly Total Cost of Care Among Patients With 24-Month Continuous Medicare Fee-for-Service Coverage'. The image is Figure 2 from the article that is linked.

Guterman EL, Kiekhofer RE, Wood AJ, Allen IE, Kahn JG, Dulaney S, Merrilees JJ, Lee K, Chiong W, Bonasera SJ, Braley TL, Hunt LJ, Harrison KL, Miller BL, Possin KL.
Care Ecosystem collaborative model and health care costs in Medicare beneficiaries with dementia: A secondary analysis of a randomized clinical trial.

JAMA Internal Medicine. 2023; 183(11):1222-1228.

PubMed Central PMC10507595
10.1001/jamainternmed.2023.4764

Photo-realistic image showing two side-by-side round white pills dissolving in deep blue-colored water.

Hoy CW, Chiong W.
Book Review: DeGrazia D, Millum J. A Theory of Bioethics. Cambridge University Press. 2021.

Kennedy Institute of Ethics Journal. 2023; 33(3):321-325.

10.1353/ken.2023.a917931

Image from Hartmann CJ, Chaturvedi A, Lujan JL on Wikimedia Commons

Hoy CW, Little SJ, Chiong W.
Using neuroscientific and clinical context to assess and manage changes in core personal traits caused by deep brain stimulation.

AJOB Neuroscience. 2023; 14(3):310-312.

PubMed Central PMC10700017
10.1080/21507740.2023.2243873

Antoniou R, Haeusermann T, Bernstein Sideman A, Fong KC, Callahan P, Miller BL, Kramer KL, Chiong W, Rankin KP.
Moral reasoning through the eyes of persons with behavioral variant frontotemporal dementia.

Frontiers in Neurology. 2023; 14:1197213.

Open Access
PubMed Central PMC10365271
10.3389/fneur.2023.1197213

Figure 2 of paper: Revised two-dimensional model of utilitarian judgment.

Antoniou R, Romero-Kornblum H, Young CJ, You M, Kramer JH, Rankin KP, Chiong W.
Contrasting two models of utilitarian reasoning.

Heliyon. 2023; 9(7):e17498.

Open Access
PubMed Central PMC10328838
10.1016/j.heliyon.2023.e17498
Preregistration
Open Data

Figure 1 of paper: open-loop and closed-loop neuromodulation.

Haeusermann T, Lechner CR, Fong KC, Bernstein Sideman A, Jaworska A, Chiong W, Dohan D.
Closed-loop neuromodulation and self-perception in clinical treatment of refractory epilepsy.

AJOB Neuroscience. 2023;14(1):32-44.

Open Access
PubMed Central PMC9007331
10.1080/21507740.2021.1958100

Photo by the Centre for Ageing Better on Unsplash

Sideman AB, Merrilees J, Dulaney S, Kiekhofer R, Braley T, Lee K, Chiong W, Miller B, Bonasera SJ, Possin KL.
''Out of the clear blue sky she tells me she loves me'': Connection experiences between caregivers and people with dementia.

Journal of the American Geriatric Society. 2023; 71(7):2172-2183.

PubMed Central PMC10500033
10.1111/jgs.18297

Figure 3 of paper: Flowchart of the Care Ecosystem Medication Review Intervention and Monitoring Process.

Liu AK, Possin KL, Cook KM, Lynch S, Dulaney S, Merrilees JJ, Braley T, Kiekhofer RE, Bonasera SJ, Allen IE, Chiong W, Clark AM, Feuer J, Ewalt J, Guterman EL, Gearhart R, Miller BL, Lee KP.
Effect of collaborative dementia care on potentially inappropriate medication use: Outcomes from the Care Ecosystem randomized clinical trial.

Alzheimer’s & Dementia. 2023; 19(5):1865-1875.

PubMed Central PMC10156873
10.1002/alz.12808

Haeusermann T, Romero-Kornblum H, Dzeng E.
Of care, cure and the in-between: COVID-19 treatment in a New York City intensive care unit

International Journal of Care and Caring. 2022; 6(1-2):67-84.

10.1332/239788221X16316503274460

Figure 1 of paper: Conceptual model of relationships among financial activity, mismanagement and abuse in dementia.

Manivannan M, Heunis J, Hooper SM, Bernstein Sideman A, Lui KP, Possin KL, Chiong W.
Use of telephone- and internet-based support to elicit and address financial abuse and mismanagement in dementia: Experiences from the Care Ecosystem study.

Journal of Alzheimer’s Disease. 2022; 86(1):219-229.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC10938943
10.3233/JAD-215284

Chiong W, Tolchin BD, Bonnie RJ, Busl K, Cruz-Flores S, Epstein LG, Greene EP, Illes J, Kirschen M, Larriviere DG, Mantri S, Rubin MA, Stern BJ, Taylor LP, on behalf of the Ethics, Law, and Humanities Committee (a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society).
Decisions with patients and families regarding aducanumab in Alzheimer disease, with recommendations for consent: AAN position statement.

Neurology. 2022; 98(4):154-159.

10.1212/WNL.0000000000013053

Sattin JA, Chiong W, Bonnie RJ, Kirschen MP, Russell JA, on behalf of the Ethics, Law, and Humanities Committee (a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society).
Consent issues in the management of acute ischemic stroke: AAN position statement.

Neurology. 2022; 98(2):73-79.

10.1212/WNL.0000000000013040

Lindbergh CA, Romero-Kornblum H, Weiner-Light S, Young JC, Fonseca C, You M, Wolf A, Staffaroni AM, Daly R, Jeste DV, Kramer JH, Chiong W, the Hillblom Aging Network.
Wisdom and fluid intelligence are dissociable in healthy older adults.

International Psychogeriatrics. 2022; 34(3):229–239.

Open Access
PubMed Central PMC8578582
10.1017/S1041610221000521
Preregistration
Open Data

Jaworska A, Chiong W.
Supported decision-making for people with dementia should focus on their values.

American Journal of Bioethics. 2021; 21(11):19–21.

Open Access
10.1080/15265161.2021.1980150

Figure 2 of paper: Utilitarian responses and personal rights dilemmas.

Antoniou R, Romero-Kornblum H, Young JC, You M, Kramer JH, Chiong W.
Reduced utilitarian willingness to violate personal rights during the COVID-19 pandemic.

PLoS One. 2021; 16(10):e0259110.

Open Access
PubMed Central PMC8535394
10.1371/journal.pone.0259110
PsyArXiv preprint
Preregistration
Open Data
Open Materials

photo by Mohamed Mahmoud Hassan on publicdomainpictures.net

Ma H, Kiekhofer RE, Hooper SM, Dulaney S, Possin KL, Chiong W.
Goals of care conversations and subsequent advance care planning outcomes for people with dementia.

Journal of Alzheimer’s Disease. 2021; 83(4):1767–1773.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC9034733
10.3233/JAD-210720

Ngo S, Kim AS, Chiong W.
Evidence for the ethics of incentivizing clinical trial enrollment?

JAMA Internal Medicine. 2021; 181(11):1488-1489.

10.1001/jamainternmed.2021.5449

Chiang S, Picard RW, Chiong W, Moss R, Worrell GA, Rao VR, Goldenholz DM.
Guidelines for conducting ethical artificial intelligence research in neurology: A systematic approach for clinicians and researchers.

Neurology. 2021; 97(13):632–640

PubMed Central PMC8480407
10.1212/WNL.0000000000012570

Chiong W, Tsou AY, Simmons Z, Bonnie RJ, Russell JA, on behalf of the Ethics, Law, and Humanities Committee (a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society).
Ethical considerations in dementia diagnosis and care: AAN position statement.

Neurology. 2021; 97(2):80-89.

10.1212/WNL.0000000000012079

Hrincu V, McDonald PJ, Connolly MB, Harrison MJ, Ibrahim GM, Naftel RP, Chiong W, Alam A, Ribary U, Illes J.
Choice and trade-offs: parent decision making for neurotechnologies for pediatric drug-resistant epilepsy.

Journal of Child Neurology. 2021; 36(11):943-949.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC8458226
10.1177/08830738211015010

Figure of paper: Responsive Neurostimulation System.

Hegde M, Chiong W, Rao VR.
New ethical and clinical challenges in “closed-loop” neuromodulation.

Neurology. 2021; 96(17):799-804.

PubMed Central PMC8166428
10.1212/WNL.0000000000011834

Mergenthaler JV, Chiong W, Dohan D, Feler J, Lechner CR, Starr PA, Arias JJ.
A qualitative analysis of ethical perspectives on recruitment and consent for human intracranial electrophysiology studies.

AJOB Neuroscience. 2021; 12(1):57-67.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC8168380
10.1080/21507740.2020.1866098

Figure 1 of paper: An objective attitude is associated with decreased relationship closeness between care-giver and care-recipient while not protecting against care-giver strain.

Zahir A, Staffaroni AM, Wickham RE, Quinn CM, Sapozhnikova A, Seidman J, Chiong W.
Caregiver “objective attitude” toward patients with neurodegenerative disease: Consequences for caregiver strain and relationship closeness.

Aging & Mental Health. 2021; 25(9):1709–1715.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC7748409
10.1080/13607863.2020.1771541

Fong KC, Chiong W.
Understanding advance directives as a component of advance care planning.

American Journal of Bioethics. 2020; 20(8):67-69.

pdf - author manuscript version
10.1080/15265161.2020.1781974

Image from https://health.mil/News/Gallery/Photos/2020/05/18/Infection-Control-2020

Goss AL, Chiong W, Hemphill JC.
Neurologists' duties in planning for triage of critical care resources in the COVID-19 pandemic.

Annals of Neurology. 2020; 88(3):431-432.

Open Access
PubMed Central PMC7405081
10.1002/ana.25852

Chiong W.
Insiders and outsiders: Lessons for neuroethics from the history of bioethics.

AJOB Neuroscience. 2020; 11(3):155-166.

Open Access
PubMed Central PMC7485591
10.1080/21507740.2020.1778118

Bernstein A, Merrilees J, Dulaney S, Harrison KL, Chiong W, Ong P, Heunis J, Choi J, Walker R, Feuer JE, Lee K, Dohan D, Bonasera SJ, Miller BL, Possin KL.
Using care navigation to address caregiver burden in dementia: A qualitative case study analysis.

Alzheimer’s & Dementia. 2020; 6(1):e12010.

Open Access
PubMed Central PMC7201177
10.1002/trc2.12010

Figure 3 of paper: The proportion of trials in which smaller immediate reward was chosen.

Beagle AJ, Zahir A, Borzello M, Kayser AS, Hsu M, Miller BL, Kramer JH, Chiong W.
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.

Cortex. 2020; 124:54-65.

pdf - author manuscript version (peer-reviewed & edited)
PubMed Central PMC7060812
10.1016/j.cortex.2019.10.009
Open Data
Open Materials

Haeusermann T, Fong KC, Lechner CR.
Book Review: Lynch, JA. The Origins of Bioethics: Remembering When Medicine Went Wrong. Michigan State University Press. 2019. 228pp. ISBN 9781611863413.

Sociology of Health & Illness. 2020; 42(4):962-963.

pdf - author manuscript version (peer-reviewed & edited)
10.1111/1467-9566.13060

Merrilees JJ, Bernstein A, Dulaney S, Heunis J, Walker R, Rah E, Choi J, Gawlas K, Carroll S, Ong P, Feuer J, Braley T, Clark AM, Lee K, Chiong W, Bonasera SJ, Miller BL, Possin KL.
The Care Ecosystem: Promoting self-efficacy among dementia family caregivers.

Dementia. 2020; 19(6)1955-1973.

PubMed Central PMC6541533
10.1177/1471301218814121

Photo-realistic image of green, yellow, red, and blue 3-dimensional wooden blocks on a flat surface.

Chiong W, Haeusermann T.
Commentary 1: Researcher integrity and contrasting obligations in interdisciplinary research.

Journal of Empirical Research on Human Research Ethics. 2019; 14(5):487-489.

PubMed Central PMC6980360
10.1177/1556264619853198a

Figure 1 of paper: Potential paths for neural devices and implications for post-trial access and maintenance.

Hendriks S, Grady C, Ramos KM, Chiong W, Fins JJ, Ford P, Goering S, Greely HT, Hutchison K, Kelly ML, Kim SYH, Klein E, Lisanby SH, Mayberg H, Maslen H, Miller FG, Rommelfanger K, Sheth SA, Wexler A.
Ethical challenges of risk, informed consent, and posttrial responsibilities in human research with neural devices: A review.

JAMA Neurology. 2019; 76(12):1506-1514.

PubMed Central PMC9395156
10.1001/jamaneurol.2019.3523

Figure 3 of paper: Zip codes of persons with dementia enrolled in the care ecosystem trial.

Possin KL, Merrilees JJ, Dulaney S, Bonasera SJ, Chiong W, Lee KP, Hooper SM, Allen IE, Braley T, Bernstein A, Rosa TD, Harrison K, Begert-Hellings H, Kornak J, Kahn JG, Naasan G, Lanata S, Clark AM, Chodos A, Gearhart R, Ritchie C, Miller BL.
Effect of collaborative dementia care via telephone and internet on quality of life, caregiver well-being, and health care use: The Care Ecosystem randomized clinical trial.

JAMA Internal Medicine. 2019; 179(12):1658-1667.

Open Access
PubMed Central PMC6777227
10.1001/jamainternmed.2019.4101

Quinn CM, Borzello M, Zahir A, Kramer JH, Chiong W.
COMT Val158Met polymorphism associated with greater susceptibility to framing effects in healthy older adults.

bioRxiv. 2019. [unrefereed preprint]

10.1101/790808
bioRxiv preprint

Image courtesy of Salvatore Spina, MD PhD

Butler PM, Chiong W.
Neurodegenerative disorders of the human frontal lobes.

Handbook of Clinical Neurology. 2019; 163:391-410.

10.1016/B978-0-12-804281-6.00021-5

Rosa TD, Possin KL, Bernstein A, Merrilees J, Dulaney S, Matuoka J, Lee KP, Chiong W, Bonasera SJ, Harrison KL, Kahn JG.
Variations in costs of a collaborative care model for dementia.

Journal of the American Geriatrics Society. 2019; 67(12):2628-2633.

PubMed Central PMC6898731
10.1111/jgs.16076

Bernstein A, Harrison KL, Dulaney S, Merrilees J, Bowhay A, Heunis J, Choi J, Feuer JE, Clark AM, Chiong W, Lee K, Braley TL, Bonasera SJ, Ritchie C, Dohan D, Miller BL, Possin KL.
The role of care navigators working with people with dementia and their caregivers.

Journal of Alzheimer’s Disease. 2019; 71(1):45-55.

PubMed Central PMC7004209
10.3233/JAD-180957

Guterman EL, Allen IE, Josephson SA, Merrilees JJ, Dulaney S, Chiong W, Lee K, Bonasera SJ, Miller BL, Possin KL.
Association between caregiver depression and emergency department use among patients with dementia.

JAMA Neurology. 2019; 76(10):1166-1173.

Open Access
PubMed Central PMC6618767
10.1001/jamaneurol.2019.1820

Chen Y, Wilson L, Kornak J, Dudley RA, Merrilees J, Bonasera SJ, Byrne CM, Lee K, Chiong W, Miller BL, Possin KL.
The costs of dementia subtypes to California Medicare fee-for-service, 2015.

Alzheimer’s & Dementia. 2019; 15(7): 899-906.

PubMed Central PMC7183386
10.1016/j.jalz.2019.03.015

Thomas ML, Martin AS, Eyler L, Lee EE, Macagno E, Devereaux M, Chiong W, Jeste DV.
Individual differences in level of wisdom are associated with brain activation during a moral decision‐making task.

Brain and Behavior. 2019; 9(6):e01302.

Open Access
PubMed Central PMC6577614
10.1002/brb3.1302

Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW.
Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

NeuroImage. Clinical. 2019; 23:101822.

Open Access
PubMed Central PMC6475809
10.1016/j.nicl.2019.101822

Ramos KM, Grady C, Greely HT, Chiong W, Eberwine J, Farahany NA, Johnson LS, Hyman SE, Rommelfanger KS, Serrano EE, Churchill JD, Gordon JA, Koroshetz WJ.
The NIH BRAIN initiative: Integrating neuroethics and neuroscience.

Neuron. 2019; 101(3):394-398.

Open Access
10.1016/j.neuron.2019.01.024

Greely HT, Grady C, Ramos KM, Chiong W, Eberwine J, Farahany NA, Johnson LS, Hyman BT, Hyman SE, Rommelfanger KS, Serrano EE.
Neuroethics guiding principles for the NIH BRAIN initiative.

Journal of Neuroscience. 2018; 38(50):10586-10588.

Open Access
PubMed Central PMC6297371
10.1523/JNEUROSCI.2077-18.2018

Vaishnav NH, Chiong W.
Informed consent for the human research subject with a neurologic disorder.

Seminars in Neurology. 2018; 38(5):539-547.

pdf - published version
10.1055/s-0038-1668077

Chiong W, Leonard MK, Chang EF.
Neurosurgical patients as human research subjects: Ethical considerations in intracranial electrophysiology research.

Neurosurgery. 2018; 83(1):29-37.

PubMed Central PMC5777911
10.1093/neuros/nyx361

Chiong W.
Challenges in communicating and understanding predictive biomarker imaging for Alzheimer disease.

JAMA Neurology. 2018; 75(1):18-19.

10.1001/jamaneurol.2017.2558

Possin KL, Merrilees J, Bonasera SJ, Bernstein A, Chiong W, Lee K, Wilson L, Hooper SM, Dulaney S, Braley T, Laohavanich S, Feuer JE, Clark AM, Schaffer MW, Schenk AK, Heunis J, Ong P, Cook KM, Bowhay AD, Gearhart R, Chodos A, Naasan G, Bindman AB, Dohan D, Ritchie C, Miller BL.
Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem.

PLoS Medicine. 2017; 14(3):e1002260.

Open Access
PubMed Central PMC5360211
10.1371/journal.pmed.1002260